195 research outputs found
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100th Anniversary of Macromolecular Science Viewpoint: Opportunities in the Physics of Sequence-Defined Polymers
Polymer science has been driven by ever-increasing molecular complexity, as polymer synthesis expands an already-vast palette of chemical and architectural parameter space. Copolymers represent a key example, where simple homopolymers have given rise to random, alternating, gradient, and block copolymers. Polymer physics has provided the insight needed to explore this monomer sequence parameter space. The future of polymer science, however, must contend with further increases in monomer precision, as this class of macromolecules moves ever closer to the sequence-monodisperse polymers that are the workhorses of biology. The advent of sequence-defined polymers gives rise to opportunities for material design, with increasing levels of chemical information being incorporated into long-chain molecules; however, this also raises questions that polymer physics must address. What properties uniquely emerge from sequence-definition? Is this circumstance-dependent? How do we define and think about sequence dispersity? How do we think about a hierarchy of sequence effects? Are more sophisticated characterization methods, as well as theoretical and computational tools, needed to understand this class of macromolecules? The answers to these questions touch on many difficult scientific challenges, setting the stage for a rich future for sequence-defined polymers in polymer physics
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Recent progress in the science of complex coacervation
Complex coacervation is an associative, liquid–liquid phase separation that can occur in solutions of oppositely-charged macromolecular species, such as proteins, polymers, and colloids. This process results in a coacervate phase, which is a dense mix of the oppositely-charged components, and a supernatant phase, which is primarily devoid of these same species. First observed almost a century ago, coacervates have since found relevance in a wide range of applications; they are used in personal care and food products, cutting edge biotechnology, and as a motif for materials design and self-assembly. There has recently been a renaissance in our understanding of this important class of material phenomena, bringing the science of coacervation to the forefront of polymer and colloid science, biophysics, and industrial materials design. In this review, we describe the emergence of a number of these new research directions, specifically in the context of polymer–polymer complex coacervates, which are inspired by a number of key physical and chemical insights and driven by a diverse range of experimental, theoretical, and computational approaches
PRISM-Based Theory of Complex Coacervation: Excluded Volume versus Chain Correlation
Aqueous solutions of oppositely charged polyelectrolytes can undergo liquid–liquid phase separation into materials known as complex coacervates. These coacervates have been a subject of intense experimental and theoretical interest. Efforts to provide a physical description of complex coacervates have led to a number of theories that qualitatively (and sometimes quantitatively) agree with experimental data. However, this agreement often occurs in a degeneracy of models with profoundly different starting assumptions and different levels of sophistication. Theoretical difficulties in these systems are similar to those in most polyelectrolyte systems where charged species are highly correlated. These highly correlated systems can be described using liquid state (LS) integral equation theories, which surpass mean-field theories by providing information on local charge ordering. We extend these ideas to complex coacervate systems using PRISM-type theories and are able to capture effects not observable in traditional coacervate models, particularly connectivity and excluded volume effects. We can thus bridge two traditional but incommensurate theories meant to describe complex coacervates: the Voorn–Overbeek theory and counterion release. Importantly, we hypothesize that a cancellation of connectivity and excluded volume effects provides an explanation for the ability of Voorn–Overbeek theory to fit experimental data despite its well-known approximations
Systems and methods for detecting molecular interactions using magnetic beads
Systems and methods are provided for detecting or measuring binding affinity between different compositions. The methods include contacting one or more magnetic beads having a surface including a first composition with a substrate having a surface including a second composition; applying a rotating magnetic field to the one or more magnetic beads effective to cause the one or more magnetic beads to move across the surface of the substrate; measuring the movement of the one or more magnetic beads across the substrate surface to determine a translational velocity; and determining a binding affinity between the first and second compositions from the translational velocity
Smoking and reverse cholesterol transport: evidence for gene-environment interaction
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/66077/1/j.1399-0004.1989.tb03201.x.pd
Self-Consistent Hopping Theory of Activated Relaxation and Diffusion of Dilute Penetrants in Dense Crosslinked Polymer Networks
We generalize and apply a microscopic force-level statistical mechanical
theory of the activated dynamics of dilute spherical penetrants in
glass-forming liquids to study the influence of permanent crosslinking in
polymer networks on the penetrant relaxation time and diffusivity over a wide
range of temperature and crosslink density. Calculations are performed for
model parameters relevant to recent experimental studies of an nm-sized organic
molecule diffusing in crosslinked PnBA networks. The theory predicts the
penetrant alpha relaxation time increases exponentially with the crosslink
fraction () dependent glass transition temperature, , which grows
roughly linearly with the square root of . Moreover, is also found
to be proportional to a geometric confinement parameter defined as the ratio of
the penetrant diameter to the mean network mesh size. The decoupling ratio of
the penetrant to polymer Kuhn segment alpha relaxation times displays a complex
non-monotonic dependence on crosslink density and temperature that can be well
collapsed based on the variable . The microscopic mechanism for
activated penetrant relaxation is elucidated and a model for the penetrant
diffusion constant that combines activated segmental dynamics and entropic mesh
confinement is proposed which results in a significantly stronger suppression
of mass transport with degree of effective supercooling than predicted for the
penetrant alpha time. This behavior corresponds to a new polymer network-based
type of decoupling of diffusion and relaxation. In contrast to the diffusion of
larger nanoparticles in high temperature rubbery networks, our analysis in the
deeply supercooled regime suggests that for the penetrants studied the mesh
confinement effects are of secondary importance relative to the consequences of
crosslink-induced slowing down of glassy activated relaxation.Comment: 42 pages and 14 figure
Von Willlebrand Adhesion to Surfaces at High Shear Rates Is Controlled by Long-Lived Bonds
Von Willebrand factor (vWF) adsorbs and immobilizes platelets at sites of injury under high-shear-rate conditions. It has been recently demonstrated that single vWF molecules only adsorb significantly to collagen above a threshold shear, and here we explain such counterintuitive behavior using a coarse-grained simulation and a phenomenological theory. We find that shear-induced adsorption only occurs if the vWF-surface bonds are slip-resistant such that force-induced unbinding is suppressed, which occurs in many biological bonds (i.e., catch bonds). Our results quantitatively match experimental observations and may be important to understand the activation and mechanical regulation of vWF activity during blood clotting
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